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Drug Profile

Olorofim - F2G

Alternative Names: F-901318

Latest Information Update: 27 Mar 2025

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At a glance

  • Originator F2G
  • Class Antifungals; Piperazines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Dihydroorotate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mycoses; Coccidioidomycosis; Invasive bronchopulmonary aspergillosis
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Mycoses
  • Phase III Invasive bronchopulmonary aspergillosis
  • Phase II Coccidioidomycosis

Most Recent Events

  • 27 Apr 2024 Antimicrobial data from preclinical studies in Mycoses presented at the 34th Congress of the European Society of Clinical Microbiology and Infectious (ESCMID-2024)
  • 27 Apr 2024 Antimicrobial data from preclinical studies in Mycoses presented at the 34th Congress of the European Society of Clinical Microbiology and Infectious (ESCMID-2024)
  • 21 Oct 2023 Efficacy data from the phase II FORMULA-OLS trial in Mycoses released by F2G

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