AZD 5312

Drug Profile

AZD 5312

Alternative Names: ARRx; AZD5312; IONIS AR 2.5Rx; ISIS ARRX; ISIS AZ1Rx; ISIS-560131; ISIS-ARRx

Latest Information Update: 11 Jan 2017

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At a glance

  • Originator Isis Pharmaceuticals
  • Developer AstraZeneca; Ionis Pharmaceuticals
  • Class Antineoplastics; Antisense oligonucleotides
  • Mechanism of Action Androgen receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Prostate cancer
  • Discontinued Solid tumours

Most Recent Events

  • 03 Oct 2017 University of Michigan Cancer Center plans the phase II ARRO-CITO trial for castration-resistant Prostate cancer (Metastatic disease, Second-line therapy or greater, Combination therapy) in USA (IV, Infusion) (NCT03300505)
  • 15 Nov 2016 Adverse events, pharmacokinetic and pharmacodynamic data from a phase I/II trial in advanced solid tumours presented at the 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR-2016)
  • 16 Jun 2016 Phase-II clinical trials in Prostate cancer (Late-stage disease) in United Kingdom and USA (IV) (Ionis Pharmaceuticals pipeline, June 2016)
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