HMPL 523

Drug Profile

HMPL 523

Alternative Names: HMPL-523; HMPL-523 acetate

Latest Information Update: 23 Jan 2017

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At a glance

  • Originator Hutchison MediPharma
  • Class Anti-inflammatories; Antirheumatics
  • Mechanism of Action Syk kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I B cell lymphoma; Haematological malignancies; Lupus vulgaris; Multiple sclerosis; Rheumatoid arthritis
  • Preclinical Chronic lymphocytic leukaemia; Inflammation

Most Recent Events

  • 27 Dec 2016 Phase-I clinical trials in B-cell lymphoma (Second-line therapy or greater) in China (PO) (NCT02857998)
  • 27 Dec 2016 Phase-I clinical trials in Haematological malignancies (Second-line therapy or greater) in China (PO) (NCT02857998)
  • 15 Nov 2016 Pharmacokinetics, pharmacodynamic and adverse event data from a phase I trial in Healthy volunteers presented at the 80th American College of Rheumatology and the 51st Annual Meeting of the Association of Rheumatology and Health Professionals (ACR/ARHP-2016)
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