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Nitric oxide inhalation - INOpulse - Bellerophon Therapeutics

Drug Profile

Nitric oxide inhalation - INOpulse - Bellerophon Therapeutics

Alternative Names: Inhaled nitric oxide - Bellerophon; inhaled NO - Bellerophon; iNO- Bellerophon; Nitric oxide-INOpulse®

Latest Information Update: 07 Aug 2023

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At a glance

  • Originator Ikaria Holdings
  • Developer Bellerophon Therapeutics
  • Class Anti-infectives; Anti-inflammatories; Antiacnes; Antiandrogens; Antibacterials; Antibronchitics; Antifibrotics; Antifungals; Antihypertensives; Antineoplastics; Antituberculars; Antivirals; Cardiovascular therapies; Diagnostic agents; Foot disorder therapies; Free radicals; Nitrogen oxides; Non-opioid analgesics; Skin disorder therapies; Small molecules; Vascular disorder therapies; Vasodilators
  • Mechanism of Action Androgen receptor antagonists; Angiogenesis inducing agents; Cell death stimulants; Guanylate cyclase stimulants; Nitric oxide donors; Reactive oxygen species modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension; Idiopathic pulmonary fibrosis
  • New Molecular Entity No

Highest Development Phases

  • Phase III Pulmonary arterial hypertension; Pulmonary hypertension
  • Phase II Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis
  • Discontinued COVID 2019 infections

Most Recent Events

  • 30 Jun 2023 Bellerophon Therapeutics terminates a phase III REBUILD trial in Pulmonary hypertension in Canada, USA (Inhalation) as the trial did not meet its primary endpoint (NCT03267108)
  • 05 Jun 2023 Efficacy and adverse events data from phase-III REBUILD trial in Pulmonary hypertension released by Bellerophon Therapeutics
  • 09 Feb 2023 National Medical Products Administration approves IND application for nitric oxide inhalation for a phase III trial in fibrotic Interstitial lung disease
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