Research programme: SNA based therapeutics - Exicure

Drug Profile

Research programme: SNA based therapeutics - Exicure

Alternative Names: AST 008; SNA constructs - Exicure; SNA targeting IL17RA - Exicure; SNA targeting IL4RA - Exicure; Spherical nucleic acid constructs - Exicure; XCUR17

Latest Information Update: 21 Nov 2017

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At a glance

  • Originator AuraSense Therapeutics
  • Developer Exicure
  • Class Nucleic acids
  • Mechanism of Action Gene modulators; Immunomodulators; Immunosuppressants; Interleukin 1 beta modulators; Interleukin 17 receptor modulators; Interleukin 4 receptor modulators; Toll-like receptor 9 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Brain cancer; Cancer; Fibrosis; Inflammation; Lymphoma; Psoriasis; Skin disorders; Solid tumours; Transplant rejection
  • Research Atopic dermatitis; Epidermolysis bullosa; Eye disorders; Gastrointestinal disorders; Respiration disorders

Most Recent Events

  • 15 Nov 2017 Exicure files an CTA application with the Bundesinstitut für Arzneimittel und Medizinprodukte in Germany for Psoriasis in the third quarter of 2017
  • 15 Nov 2017 Medicines and Healthcare products Regulatory Agency approves IND application for phase I trial of AST 008 in United Kingdom in the third quarter of 2017
  • 14 Nov 2017 Exicure plans a phase I trial of AST 008 in Healthy volunteers in USA (SC) and United Kingdom (SC) in the fourth quarter of 2017 (NCT03086278)
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