Drug Profile


Alternative Names: APL2

Latest Information Update: 04 Oct 2017

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At a glance

  • Originator Apellis Pharmaceuticals
  • Class Antianaemics; Cyclic peptides; Eye disorder therapies
  • Mechanism of Action Complement C3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Autoimmune haemolytic anaemia; Dry age-related macular degeneration
  • Phase I Ischaemia; Paroxysmal nocturnal haemoglobinuria; Wet age-related macular degeneration

Most Recent Events

  • 28 Sep 2017 Apellis Pharmaceuticals initiate a phase I trial in Paroxysmal nocturnal haemoglobinuria (In volunteers) in Australia (ACTRN12617000982314p)
  • 31 Aug 2017 Phase-II clinical trials in Autoimmune haemolytic anaemia in USA (SC) (NCT03226678)
  • 29 Aug 2017 Apellis Pharmaceuticals completes enrolment in the phase II FILLY trial for Dry age-related macular degeneration in USA, Australia and New Zealand before August 2017 (NCT02503332)
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