Drug Profile


Alternative Names: Ang2 antibody/aflibercept; Ang2 antibody/Eylea; REGN 910-3

Latest Information Update: 12 Nov 2016

Price : $50

At a glance

  • Originator Regeneron Pharmaceuticals
  • Class Eye disorder therapies; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action Angiogenesis inhibitors; Angiopoietin-2 inhibitors; Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diabetic macular oedema; Wet age-related macular degeneration

Most Recent Events

  • 24 Mar 2016 Aflibercept/nesvacumab licensed to Bayer worldwide, except USA, for the treatment of Eye disorders
  • 01 Mar 2016 Phase-II clinical trials in Diabetic macular oedema in USA (Intravitreous) (NCT02712008)
  • 01 Feb 2016 Phase-II clinical trials in Wet age-related macular degeneration (In adults, In the elderly) in USA (Intravitreous) (NCT02713204)
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