Drug Profile


Alternative Names: 5(R)-5-hydroxytriptolide; Leitengshu; LLDT-8; LLDT-8 cpd; LTS - Shanghai Pharmaceuticals Holding; T8

Latest Information Update: 15 Jun 2017

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At a glance

  • Originator Shanghai Institute of Materia Medica
  • Developer Shanghai Pharmaceuticals Holding
  • Class Anti-inflammatories; Antineoplastics; Antirheumatics; Diterpenes; Herbal medicines
  • Mechanism of Action Immunostimulants; Interferon-gamma expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Rheumatoid arthritis

Most Recent Events

  • 12 Oct 2016 Phase-I/II development is ongoing in China (PO)
  • 01 Jun 2014 Phase-I/II clinical trials in Rheumatoid arthritis in China (PO)
  • 01 Jul 2006 Preclinical trials in Rheumatoid arthritis in China (PO)
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