JCAR 014

Drug Profile

JCAR 014

Alternative Names: 4-1BB-modified CAR CD8+ central memory and CD4+ T lymphocyte therapy - Juno Therapeutics; anti-CD19-4-1BB-zeta modified CAR CD8+ central memory and CD4+ T lymphocyte therapy - Juno Therapeutics; anti-CD19/4-1BB/zeta modified CAR CD8+ central memory and CD4+ T lymphocyte therapy - Juno Therapeutics; JCAR014

Latest Information Update: 13 Jul 2017

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At a glance

  • Originator Juno Therapeutics
  • Developer Fred Hutchinson Cancer Research Center; Juno Therapeutics; MedImmune; National Cancer Institute (USA)
  • Class Cancer vaccines; CAR-T cell therapies
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Gene transference; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Acute lymphoblastic leukaemia; Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma

Most Recent Events

  • 02 Jun 2017 Updated adverse events data from a phase I/II trial in Non-Hodgkin's lymphoma, Acute lymphoblastic leukaemia and Chronic lymphocytic leukaemia presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 04 May 2017 Clinical trials in Chronic lymphocytic leukaemia (Combination therapy) (IV) before May 2017
  • 03 Dec 2016 Efficacy and adverse events data from a phase I/II trial in Chronic lymphocytic leukaemia presented at the 58th Annual Meeting and Exposition of the American Society of Haematology (ASH-Hem-2016)
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