MK 8591

Drug Profile

MK 8591

Alternative Names: 4-ethynyl-2-fluoro-2-deoxyadenosine; EFdA; MK-8591

Latest Information Update: 18 Jul 2017

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antiretrovirals
  • Mechanism of Action Nucleoside reverse transcriptase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I HIV-1 infections
  • Preclinical HIV-2 infections

Most Recent Events

  • 07 Sep 2017 Merck Sharp & Dohme plans a phase II trial for HIV-1 infections(Combination therapy, Treatment-naive) (NCT03272347)
  • 11 May 2017 Merck Sharp & Dohme completes the phase I MK-8591-003 trial for HIV-1 infections (Monotherapy, Treatment -naive) in Germany (PO) (NCT02217904)
  • 17 Apr 2017 Chemical structure information added
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