PT 2385

Drug Profile

PT 2385

Alternative Names: HIF 2a; PT-2385

Latest Information Update: 11 May 2017

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At a glance

  • Originator University of Texas Southwestern Medical Center
  • Developer National Cancer Institute (USA); Peloton Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Von Hippel-Lindau disease
  • Phase I Renal cell carcinoma
  • Preclinical Glioblastoma

Most Recent Events

  • 17 Jul 2017 Sidney Kimmel Comprehensive Cancer Center plans a phase II trial for Glioblastoma (Recurrent) in USA in August 2017 (NCT03216499)
  • 01 Apr 2017 Phase-II clinical trials in Von Hippel-Lindau disease in USA (PO) (NCT03108066)
  • 06 Dec 2016 Preclinical trials in Glioblastoma in USA (PO) before December 2016
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