PF 4518600

Drug Profile

PF 4518600

Alternative Names: PF-04518600; PF-8600

Latest Information Update: 17 Oct 2017

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At a glance

  • Originator Pfizer
  • Developer M. D. Anderson Cancer Center; National Cancer Institute (USA); Pfizer; University of Southern California
  • Class Antibodies; Antineoplastics
  • Mechanism of Action OX40 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Renal cell carcinoma
  • Phase I/II Solid tumours

Most Recent Events

  • 08 Sep 2017 Updated adverse events data from a phase I trial in Solid tumours presented at the 42nd European Society for Medical Oncology Congress (ESMO-2017)
  • 02 Aug 2017 Phase-I/II clinical trials in Solid tumours (Combination therapy, Late-stage disease) in USA (IV) (NCT03217747)
  • 19 Jul 2017 Phase-II clinical trials in Renal cell carcinoma (Combination therapy, Metastatic disease, Second line or greater) in USA (IV) (NCT03092856)
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