E6 TCR

Drug Profile

E6 TCR

Alternative Names: anti-HPV-16 E6 TCR; HPV-16 E6 TCR gene therapy

Latest Information Update: 15 Jul 2017

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At a glance

  • Originator Kite Pharma; National Cancer Institute (USA)
  • Class Cell therapies; Gene therapies; T lymphocyte cell therapies
  • Mechanism of Action Gene transference; Human papillomavirus E6 T cell receptor expression modulators; T-cell receptor antigen antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Anal cancer; Cervical cancer; Oropharyngeal cancer; Penile cancer; Vulvovaginal cancer

Most Recent Events

  • 29 Jun 2017 National Cancer Institute plans a phase I trial for Cervical intraepithelial neoplasia in USA (NCT03197025)
  • 02 Jun 2017 Adverse events and efficacy data from a phase II trial in HPV-associated Anal cancer, Cervical cancer, Oropharyngeal cancer, Penile cancer, Vulvovaginal cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 06 Apr 2017 Discontinued - Phase-II for Anal cancer, Cervical cancer, Oropharyngeal cancer, Penile cancer, and Vulvovaginal cancer (Recurrent, Refractory metastatic disease, Second-line therapy or greater) in USA (IV), because E6 TCR was not listed on Kite Pharma pipeline April 2017
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