APVO 414

Drug Profile

APVO 414

Alternative Names: Anti-PSMA-X-Anti-CD3-ADAPTIR molecule; ES 414; MOR 209 ES 414; MOR-209/ES-414

Latest Information Update: 04 Sep 2017

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At a glance

  • Originator Aptevo Therapeutics; Emergent BioSolutions
  • Developer Aptevo Therapeutics; MorphoSys
  • Class Antineoplastics; Bispecific antibodies; Proteins
  • Mechanism of Action CD3 antigen inhibitors; Cytotoxic T lymphocyte modulators; Glutamate carboxypeptidase II inhibitors; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Prostate cancer

Most Recent Events

  • 31 Aug 2017 Aptevo Therapeutics and MorphoSys ends joint development and commercialisation agreement for MOR209 ES414 in Prostate cancer
  • 31 Aug 2017 Preliminary immunogenicity and adverse events data from a phase I trial in Prostate cancer released by Aptevo Therapeutics
  • 31 Mar 2017 MOR209 ES414 is available for licensing as of 31 Mar 2017. http://aptevotherapeutics.com/
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