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Ravulizumab - Alexion AstraZeneca Rare Disease

Drug Profile

Ravulizumab - Alexion AstraZeneca Rare Disease

Alternative Names: ALXN 1210; ALXN 1810; ravulizumab-cwvz; Ultomiris

Latest Information Update: 26 Mar 2024

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At a glance

  • Originator Alexion Pharmaceuticals
  • Developer Alexion AstraZeneca Rare Disease; AstraZeneca
  • Class Anti-inflammatories; Antithrombotics; Eye disorder therapies; Monoclonal antibodies; Urologics
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Haemolytic uraemic syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Haemolytic uraemic syndrome; Myasthenia gravis; Paroxysmal nocturnal haemoglobinuria
  • Registered Neuromyelitis optica
  • Phase III Acute kidney injury; Thrombotic microangiopathies
  • Phase II IgA nephropathy; Lupus nephritis
  • Discontinued Acute lung injury; Amyotrophic lateral sclerosis; COVID-19 pneumonia; Dermatomyositis; SARS-CoV-2 acute respiratory disease

Most Recent Events

  • 25 Mar 2024 Registered for Neuromyelitis optica in USA (IV)
  • 04 Mar 2024 Alexion Pharmaceuticals plans a phase III trial for IgA nephropathy (Treatment-experienced) in the US, Argentina, Australia, Belgium, Brazil, Canada, Chile, France, Germany, Greece, Italy, Japan, South Korea, Mexico, Netherlands, Poland, Saudi Arabia, Spain, Taiwan, Thailand, Turkey (IV, Infusion), in April 2024 (NCT06291376)
  • 15 Feb 2024 Discontinued - Phase-II/III for Dermatomyositis (Treatment-experienced) in Italy, South Korea, United Kingdom, USA, Spain, Japan, Germany, France (IV) (Alexion AstraZeneca Rare Disease pipeline, February 2024)
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