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Avoplacel - Pluri

Drug Profile

Avoplacel - Pluri

Alternative Names: Placenta-derived cell therapy - Pluri; PLX-R-18; PLX-RAD

Latest Information Update: 12 Apr 2024

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At a glance

  • Originator Hadassah Medical School; Pluristem Therapeutics
  • Developer Case Western Reserve University; Fukushima Medical University; Hadassah Medical School; National Institute of Allergy and Infectious Diseases; Pluri; United States Department of Defense
  • Class Stem cell therapies
  • Mechanism of Action Bone marrow cell stimulants; Cell differentiation modulators; Cell replacements; Stem cell modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute radiation syndrome; Aplastic anaemia; Preeclampsia; IgA nephropathy; Graft-versus-host disease
  • New Molecular Entity No

Highest Development Phases

  • Phase II Acute radiation syndrome
  • Phase I Graft-versus-host disease
  • No development reported Aplastic anaemia; Chemical burns

Most Recent Events

  • 08 Apr 2024 Pluri has patent protection for System and Methods for Immune Cells Expansion and Activation in Large Scale in the US
  • 11 Jul 2023 Pharmacodynamics data from a phase II trial in Acute radiation syndrome released by Pluri
  • 06 Jan 2023 Avoplacel is still in phase-I development in Graft-versus-host-disease (In the elderly, In adults) in Israel (IM, Injection) (Pluristem Therapeutics pipeline, January 2023)
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