Drug Profile


Alternative Names: ACY 241; HDAC-IN-2

Latest Information Update: 08 Sep 2017

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At a glance

  • Originator Dana-Farber Cancer Institute; Harvard University
  • Developer Celgene Corporation
  • Class Antineoplastics; Small molecules
  • Mechanism of Action HDAC6 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Multiple myeloma
  • Phase I Malignant melanoma; Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 07 Apr 2017 Celgene completes a phase I trial in Malignant melanoma (Combination therapy, Late-stage disease, Inoperable/Unresectable) in USA (PO) (NCT02935790)
  • 12 Dec 2016 Chemical structure information added
  • 04 Dec 2016 Efficacy and safety data from a phase Ia/Ib clinical trial in Multiple myeloma released by Acetylon
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