Drug Profile


Alternative Names: CAR NKG2D; CAR-T NKR-2; CM-CS-1; NKR 2 T-cell; NKR-2; NKR-2 T-cell immunotherapy; NKR-T cells

Latest Information Update: 08 Jan 2017

Price : $50

At a glance

  • Originator Dartmouth College
  • Developer Celyad; Dana-Farber Cancer Institute
  • Class Antineoplastics; CAR-T cell therapies; T lymphocyte cell therapies
  • Mechanism of Action Angiogenesis inhibitors; Cytotoxic T lymphocyte stimulants; Immunostimulants; NK cell lectin-like receptor subfamily K modulators; Regulatory T lymphocyte inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Haematological malignancies; Solid tumours

Most Recent Events

  • 05 Jan 2017 Phase-I/II clinical trials in Solid tumours in Belgium (IV)
  • 24 Nov 2016 Federal agency for Medicines and Health products approves IND application to initiate phase Ib/IIa trial for NKR-2 in Solid tumours and haematological tumours
  • 18 Nov 2016 Efficacy and adverse events data from the phase I portion of a phase I/II trial in Haematological malignancies presented at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-2016)
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