Drug Profile


Alternative Names: CAR NKG2D; CAR-T NKR-2; CM-CS-1; NKR 2 T-cell; NKR-2; NKR-2 T-cell immunotherapy; NKR-T cells

Latest Information Update: 29 Mar 2017

Price : $50

At a glance

  • Originator Dartmouth College
  • Developer Celyad; Dana-Farber Cancer Institute
  • Class Antineoplastics; CAR-T cell therapies; T lymphocyte cell therapies
  • Mechanism of Action Angiogenesis inhibitors; Cytotoxic T lymphocyte stimulants; Immunostimulants; NK cell lectin-like receptor subfamily K modulators; Regulatory T lymphocyte inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Acute myeloid leukaemia; Haematological malignancies; Multiple myeloma; Solid tumours

Most Recent Events

  • 08 Mar 2017 Th US FDA approves IND application for the phase I/II THINK trial for Solid tumours
  • 16 Feb 2017 Phase-I/II clinical trials in Acute myeloid leukaemia (Second-line therapy or greater) in Belgium (IV)
  • 16 Feb 2017 Phase-I/II clinical trials in Multiple myeloma (Second-line therapy or greater) in Belgium (IV)
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