APN 401

Drug Profile

APN 401

Alternative Names: APN401; siRNA-transfected PBMC APN401; siRNA-transfected peripheral blood mononuclear cells - Apeiron

Latest Information Update: 29 Aug 2017

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At a glance

  • Originator Apeiron Biologics
  • Developer Apeiron Biologics; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (USA)
  • Class Antineoplastics; Cell therapies; Small interfering RNA
  • Mechanism of Action CBLB protein expression inhibitors; RNA interference; Ubiquitin-protein ligase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 28 Apr 2017 Apeiron Biologics initiates enrolment in a phase I trial in Solid tumours (Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT03087591)
  • 24 Mar 2017 Wake Forest University Health Sciences and National Cancer Institute plan a phase I trial for Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Recurrent, Second-line therapy or greater) in USA (NCT03087591)
  • 04 Oct 2016 APEIRON Biologics plans a phase II trial for Cancer
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