Drug Profile


Alternative Names: AKCEA-APO(a)-LRx; IONIS-APO(a)-LRx; ISIS 681257; ISIS-APO(a)-LRx; ISIS-APOALRx

Latest Information Update: 06 Apr 2017

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At a glance

  • Originator Isis Pharmaceuticals
  • Developer Akcea Therapeutics; Ionis Pharmaceuticals
  • Class Antihyperlipidaemics; Antisense oligonucleotides
  • Mechanism of Action Apolipoprotein A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hyperlipoproteinaemias

Most Recent Events

  • 30 Mar 2017 Akcea Therapeutics plans a phase III trial for hyperlipoproteinaemia
  • 07 Mar 2017 Phase-II clinical trials in Hyperlipoproteinaemia in USA (SC) (NCT03070782)
  • 06 Jan 2017 Ionis Pharmaceuticals, Akcea Therapeutics and Novartis enter into an optional licensing agreement to co-promote and co-develop AKCEA APO(a) LRx for Hyperlipoproteinaemia
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