Drug Profile


Alternative Names: Cilastatin/relebactam/imipenem; IMI/REL; Imipenem/cilastatin/relebactam; Imipenem/relebactam/cilastatin; MK-7655A; Relebactam + imepenem/cilastatin; Relebactam/cilastatin/imipenem; Relebactam/imipenem/cilastatin

Latest Information Update: 12 Oct 2017

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antibacterials; Azabicyclo compounds; Carbapenems; Cyclopropanes; Piperidines; Small molecules; Thienamycins
  • Mechanism of Action Beta lactamase inhibitors; Cell wall inhibitors; Exopeptidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase III Bacterial infections; Intra-abdominal infections; Pneumonia; Urinary tract infections
  • Phase I Gram-negative infections

Most Recent Events

  • 04 Oct 2017 Phase-III clinical trials in Intra-abdominal infections in Japan (IV) (NCT03293485)
  • 04 Oct 2017 Phase-III clinical trials in Urinary tract infections in Japan (IV) (NCT03293485)
  • 18 Sep 2017 Merck completes a phase III trial in Bacterial infections (Treatment-resistant) in Brazil, Colombia, Estonia, Germany, Italy, Peru, Romania, Latvia, Greece, Lithuania, South Korea and Turkey (IV) (NCT02452047)
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