Drug Profile


Alternative Names: Coversin; EV 576; PAS-coversin; PASylated Coversin; rEV 576; Tissue targeted Coversin™ - Akari

Latest Information Update: 31 Jul 2017

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At a glance

  • Originator Evolutec
  • Developer Akari Therapeutics; Evolutec
  • Class Anti-inflammatories; Recombinant proteins
  • Mechanism of Action Complement C5a inhibitors; Leukotriene B4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Guillain-Barre syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Haemolytic uraemic syndrome; Paroxysmal nocturnal haemoglobinuria
  • Preclinical Bullous pemphigoid; Conjunctivitis; Guillain-Barre syndrome; Myasthenia gravis; Sjogren's syndrome
  • Discontinued Asthma; Autoimmune disorders; Inflammation

Most Recent Events

  • 20 Jul 2017 Akari Therapeutics plans a clinical trial for C5 and LTB4 mediated disorder in the second half of 2017 (Akari website, July 2017)
  • 22 Jun 2017 Interim efficacy and adverse events data from a phase-II trial in Paroxysmal nocturnal haemoglobinuria presented at the 22nd Congress of the European Haematology Association (EHA-2017)
  • 24 Apr 2017 Akari plans a phase II trial for Haemolytic uraemic syndrome in the second quarter of 2017
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