GPC3-CAR-T cell therapy

Drug Profile

GPC3-CAR-T cell therapy

Alternative Names: anti-GPC3 CAR T; CAR T cells redirected to Glypican-3; CAR-GPC3 T-cell; Glypican-3-chimeric-antigen-receptor-T-cell-therapy; GPC3-CAR/CSG-GPC3; KJgpc3 001

Latest Information Update: 11 Jun 2017

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At a glance

  • Originator CARsgen
  • Developer CARsgen; Shanghai Jiao Tong University
  • Class Antineoplastics; CAR-T cell therapies
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Gene transference; Glypican 3 modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase I Hepatocellular carcinoma
  • Clinical Phase Unknown Breast cancer; Gastric cancer; Lung cancer

Most Recent Events

  • 05 Jun 2017 Preliminary efficacy and adverse events data from a phase I trial in Hepatocellular carcinoma released by CARsgen Therapeutics
  • 05 Jun 2017 CARsgen Therapeutics plans a phase I/II trial
  • 25 Apr 2017 CARsgen terminates a phase I trial in Hepatocellular carcinoma (In adults, In the elderly, Late-stage disease, Refractory metastatic disease) in China for reason not related to safety, efficacy, feasibility, or funding issues (Parenteral) (NCT02395250)
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