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Fadraciclib - Cyclacel Pharmaceuticals

Drug Profile

Fadraciclib - Cyclacel Pharmaceuticals

Alternative Names: CYC-065

Latest Information Update: 21 Feb 2024

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At a glance

  • Originator Cyclacel Pharmaceuticals
  • Class Amines; Antineoplastics; Purines; Pyridines; Small molecules
  • Mechanism of Action Cyclin dependent kinase 9 inhibitors; Cyclin-dependent kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Leukaemia; Lymphoma; Myelodysplastic syndromes; Solid tumours
  • Preclinical T-cell prolymphocytic leukaemia
  • No development reported Neuroblastoma

Most Recent Events

  • 06 Feb 2024 Cyclacel Pharmaceuticals suspends a phase I/II trials in Myelodysplastic syndromes (Monotherapy, Refractory metastatic disease, Second-line therapy or greater) and Leukaemia in USA (PO) due to slow enrollment and financial limitations (NCT05168904)
  • 18 Dec 2023 Efficacy and adverse events data from a Phase-I/II clinical trials in Solid tumours released by Cyclacel Pharmaceuticals
  • 09 Dec 2023 Preclinical trials in T-cell prolymphocytic leukaemia in USA (unspecified route), prior to December 2023
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