Drug Profile
Pegzilarginase - Spyre Therapeutics
Alternative Names: AEB-1102; AERase; Co-ArgI-PEG - Spyre Therapeutics; Co-ArgI-PEG modified human arginase I - Spyre Therapeutics; Loargys; Optimised human arginase I - Spyre Therapeutics; PEG-arginase - Spyre Therapeutics; Pegarginase - Spyre TherapeuticsLatest Information Update: 26 Dec 2023
Price :
$50
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At a glance
- Originator Aeglea Biotherapeutics
- Developer Merck AG; Spyre Therapeutics
- Class Antineoplastics; Enzymes; Immunotherapies; Polyethylene glycols; Recombinant proteins; Ureohydrolases
- Mechanism of Action Arginase replacements
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Registered Hyperargininaemia
- Phase I/II Small cell lung cancer
- No development reported Non-small cell lung cancer; Solid tumours
- Discontinued Acute myeloid leukaemia; Myelodysplastic syndromes
Most Recent Events
- 21 Dec 2023 Preregistration for Hyperargininaemia (In adolescents, In children, In the elderly, In adults) in United Kingdom (IV) Prior to December 2023
- 21 Dec 2023 Registered for Hyperargininaemia (In adolescents, In children, In the elderly, In adults) in United Kingdom (IV)
- 21 Dec 2023 Pegzilarginase - Aeglea BioTherapeutics receives Orphan Drug status for Hyperargininaemia (In adolescents, In adults, In children, In the elderly) in United Kingdom