VX 440

Drug Profile

VX 440

Alternative Names: VX-440

Latest Information Update: 10 Oct 2017

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At a glance

  • Originator Vertex Pharmaceuticals
  • Class
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator stimulants; Ion channel agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cystic fibrosis

Most Recent Events

  • 01 Aug 2017 Vertex Pharmaceuticals completes a phase II trial in Cystic fibrosis (In adolescents, In adults, In the elderly, Combination therapy) in USA, Australia, Austria, Belgium, Canada, Denmark, Germany, Italy, Spain, Netherlands and United Kingdom (PO) (NCT02951182) (EudraCT2016-000454-36)
  • 18 Jul 2017 Efficacy and events data from a phase II trial in Cystic fibrosis released by Vertex Pharmaceuticals
  • 23 Feb 2017 Vertex Pharmaceuticals has patent protection for VX 440 in USA and countries outside USA (Vertex Pharmaceuticals form 10-K, filed in February 2017)
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