Cytosine deaminase herpes simplex virus-1/thymidine kinase fusion gene therapy

Drug Profile

Cytosine deaminase herpes simplex virus-1/thymidine kinase fusion gene therapy

Alternative Names: Ad5-CD/TKrep; Ad5-yCD/mutTKSR39rep-ADP; Ad5-yCD/mutTKSR39rep-hIL12; Radiation-sensitising gene therapy - NewGenPharm/Henry Ford Health System; Theragene

Latest Information Update: 20 Sep 2017

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At a glance

  • Originator Henry Ford Health System
  • Developer Henry Ford Health System; NewGenPharm
  • Class Gene therapies; Gene-directed enzyme-prodrug therapies
  • Mechanism of Action Gene transference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Pancreatic cancer
  • No development reported Prostate cancer

Most Recent Events

  • 01 Jul 2017 Phase-I clinical trials in Pancreatic cancer (Metastatic disease, Combination therapy) in USA (Intratumoural) (NCT03281382)
  • 01 Aug 2016 Seoul National University Hospital initiates enrolment in a phase trial for Pancreatic cancer (Combination therapy) in South Korea (Parenteral) (NCT02894944)
  • 26 Nov 2015 No recent reports on development identified - Phase-II for Prostate cancer in South Korea (Intraprostatic)
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