RO 6874281

Drug Profile

RO 6874281

Alternative Names: aFAP-IL2v; FAP-IL2v; FAP-IL2v FP; RG 7461; RO6874281

Latest Information Update: 14 Sep 2017

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At a glance

  • Originator Roche
  • Class Antibodies; Antineoplastics; Interleukins; Recombinant fusion proteins
  • Mechanism of Action Fibroblast activation protein antagonists; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Renal cell carcinoma; Solid tumours

Most Recent Events

  • 20 Mar 2017 Phase-I clinical trials in Renal cell carcinoma (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Canada, United Kingdom, Italy after March 2017 (IV) (NCT03063762)
  • 24 Feb 2017 Phase-I clinical trials in Renal cell carcinoma (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Combination therapy) in Spain (IV) (NCT03063762)
  • 01 Feb 2017 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in Netherlands and Spain (IV) (NCT02627274)
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