NKTR 214

Drug Profile

NKTR 214

Alternative Names: NKTR-214

Latest Information Update: 19 Sep 2017

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At a glance

  • Originator Nektar Therapeutics; University of Texas M. D. Anderson Cancer Center
  • Developer Bristol-Myers Squibb; Nektar Therapeutics; Takeda; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Cytokines
  • Mechanism of Action CD8 positive T lymphocyte stimulants; Immunostimulants; Interleukin-2 receptor beta subunit agonists; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Sarcoma
  • Phase I/II Bladder cancer; Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours
  • Preclinical Lymphoma

Most Recent Events

  • 12 Sep 2017 Phase-II clinical trials in Sarcoma (Combination therapy) in USA (IV) (NCT03282344)
  • 09 Jun 2017 Nektar Therapeutics initiates the phase Ib/II PROPEL trial for Malignant melanoma, Non-small cell lung cancer and Bladder cancer (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater) in USA (NCT03138889)
  • 06 Jun 2017 Interim adverse events data from a phase I/II trial in presented at 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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