Bupropion/dextromethorphan - Axsome Therapeutics

Drug Profile

Bupropion/dextromethorphan - Axsome Therapeutics

Alternative Names: AXS-05

Latest Information Update: 18 Jul 2017

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At a glance

  • Developer Axsome Therapeutics
  • Class Antidepressants; Morphinans; Propiophenones; Small molecules
  • Mechanism of Action Adrenergic receptor antagonists; Adrenergic uptake inhibitors; Dopamine uptake inhibitors; Nicotinic receptor antagonists; NMDA receptor antagonists; Norepinephrine plasma membrane transport protein inhibitors; Serotonin plasma membrane transport protein inhibitors; Sigma-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase III Depressive disorders
  • Phase II/III Agitation

Most Recent Events

  • 17 Jul 2017 Phase-II/III clinical trials in Agitation in USA (PO)
  • 08 May 2017 Bupropion/dextromethorphan - Axsome Therapeutics receives Fast Track designation for Agitation [PO] (In volunteers) in USA
  • 07 Mar 2017 Axsome Therapeutics plans a phase II/III trial to assess the efficacy and safety of bupropion/dextromethorphan in patients with Alzheimer's disease agitation in the second quarter of 2017
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