Grazoprevir/ruzasvir/uprifosbuvir - Merck & Co

Drug Profile

Grazoprevir/ruzasvir/uprifosbuvir - Merck & Co

Alternative Names: Grazoprevir/MK-3682/MK-8408; Grazoprevir/MK-3682/ruzasvir; Grazoprevir/ruzasvir/MK-3682; Grazoprevir/uprifosbuvir/ruzasvir; MK-3682/grazoprevir/ruzasvir; MK-3682/ruzasvir/grazoprevir; MK-3682B; MK-5172/MK-3682/MK-8408; MK3; Ruzasvir/grazoprevir/MK-3682; Ruzasvir/grazoprevir/uprifosbuvir; Ruzasvir/MK-3682/grazoprevir; Ruzasvir/uprifosbuvir/grazoprevir; Uprifosbuvir/grazoprevir/ruzasvir; Uprifosbuvir/ruzasvir/grazoprevir

Latest Information Update: 13 Oct 2017

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At a glance

  • Originator Merck & Co
  • Class Antivirals; Macrocyclic compounds; Small molecules; Uracil nucleotides
  • Mechanism of Action Hepatitis C virus NS 5 protein inhibitors; Hepatitis C virus NS3 protein inhibitors; Hepatitis C virus NS4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Hepatitis C

Most Recent Events

  • 29 Sep 2017 Discontinued - Phase-III for Hepatitis C in Denmark, Lithuania (PO)
  • 29 Sep 2017 Merck terminates a phase II trial in Hepatitis C based on a review of phase II efficacy data in Belgium (PO) (EudraCT2016-000620-26)
  • 29 Sep 2017 Merck terminates a phase III trial in Hepatitis C based on a review of phase II efficacy data in France, Denmark and Lithuania (PO) (EudraCT2017-001463-21)
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