Drug Profile


Alternative Names: Donesta; E4

Latest Information Update: 18 Sep 2017

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At a glance

  • Originator Pantarhei Bioscience
  • Class Gonadal steroid hormones; Hormonal replacements; Oral contraceptives; Small molecules
  • Mechanism of Action Estrogen receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Atrophic vaginitis; Breast cancer; Osteoarthritis; Pregnancy; Vasomotor symptoms
  • Phase I Migraine; Prostate cancer
  • Discontinued Cardiovascular disorders; Multiple sclerosis; Sjogren's syndrome

Most Recent Events

  • 05 Dec 2017 Pantarhei Oncology plans a phase II trial for Prostate Cancer in the Netherlands (NCT03361969)
  • 02 Aug 2017 Estetra completes a phase I trial in Pregnancy (Prevention, In volunteers) in Bulgaria (PO) (NCT03075956)
  • 01 Jun 2017 Phase-I/II clinical trials in Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in Germany (Tablet) (NCT02718144)
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