Drug Profile


Alternative Names: Anti-MAGE A3 HLA-A-01-restricted TCR; Anti-MAGE-A3-DP4-TCR; Anti-MAGE-A3-TCR

Latest Information Update: 04 Oct 2017

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At a glance

  • Originator National Cancer Institute (USA)
  • Developer Kite Pharma; National Cancer Institute (USA)
  • Class Cell therapies
  • Mechanism of Action Gene transference; MAGEA-3-protein-modulators; T-cell receptor antigen modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 03 Oct 2017 Kite Pharma has been acquired by Gilead Sciences
  • 05 Oct 2016 National Cancer Institute reinitiates patient enrolment in a phase-I/II trial in Solid tumours (Second-line therapy or greater, Combination therapy, Late-stage disease) in USA (IV) (NCT02111850)
  • 16 Apr 2016 Interim efficacy data from a phase I/II trial in Solid tumours presented at the 107th Annual Meeting of the American Association for Cancer Research (AACR-2016)
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