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ZEN 3694

Drug Profile

ZEN 3694

Alternative Names: BETi ZEN-3694; ZEN-003694; ZEN-3694

Latest Information Update: 22 Feb 2024

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At a glance

  • Originator University of Pittsburgh; Zenith Epigenetics
  • Developer National Cancer Institute (USA); Pfizer; Zenith Epigenetics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Bromodomain and extraterminal domain protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer
  • Phase I/II Carcinoma; Lymphoma
  • No development reported Haematological malignancies; Lung cancer

Most Recent Events

  • 23 Jan 2024 University of Pittsburgh in collaboration with GSK initiates enrollment in a phase I clinical trial in Solid tumours (Combination therapy, Metastatic disease, Recurrent) in USA (PO) (NCT06161493)
  • 06 Dec 2023 Haider Mahdi plans a phase I trial for Solid tumours (Metastatic disease, Second-line therapy or greater, Combination therapy) in the USA (PO) in December 2023 (NCT06161493)
  • 18 Jul 2023 National Cancer Institute in collaboration with NRG Oncology plans a phase Ib trial for Ovarian Cancer and Endometrial Cancer (Combination therapy, Recurrent, Second-line therapy or greater) in August 2023 (PO) (NCT05950464)
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