Ruxolitinib deuterated

Drug Profile

Ruxolitinib deuterated

Alternative Names: CTP-543; Deuterated ruxolitinib; Deuterium ruxolitinib analogue - Concert Pharmaceuticals

Latest Information Update: 10 Aug 2017

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At a glance

  • Originator Concert Pharmaceuticals
  • Class 2 ring heterocyclic compounds; Cyclopentanes; Nitriles; Organic deuterium compounds; Pyrazoles; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules
  • Mechanism of Action Janus kinase 1 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Alopecia areata

Most Recent Events

  • 11 Jul 2017 US FDA removes clinical hold from a phase IIa trial for Alopecia areata
  • 30 Jun 2017 Concert Pharmaceuticals files a petition for a Post Grant Review with the Patent Trial and Appeal Board to challenge validity of a patent covering deuterated ruxolitinib analogues in USA
  • 17 May 2017 US FDA places clinical hold on a phase IIa trial for Alopecia areata
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