Drug Profile


Alternative Names: Anti-GITR-agonist-antibody-Incyte; INCAGN-1876

Latest Information Update: 21 Feb 2017

Price : $50

At a glance

  • Originator 4-Antibody; Ludwig Institute for Cancer Research
  • Developer Agenus; Ludwig Institute for Cancer Research
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action TNFRSF18 protein stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Preclinical Cancer

Most Recent Events

  • 14 Feb 2017 Incyte and Agenus amend licensing agreement from profit-sharing agreement to royalty bearing agreement
  • 22 Jun 2016 Phase-I/II clinical trials in Solid tumours in USA (Parenteral) (NCT02697591)
  • 26 Feb 2016 Agenus and Incyte plan a phase I trial of INCAGN 01876 for Solid tumours (Metastatic disease, Second-line therapy or greater) (NCT02697591)
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