Drug Profile


Alternative Names: Anti-GITR-agonist-antibody-Incyte; INCAGN 01876; INCAGN-1876

Latest Information Update: 28 Apr 2017

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At a glance

  • Originator 4-Antibody; Ludwig Institute for Cancer Research
  • Developer Agenus; Incyte Corporation; Ludwig Institute for Cancer Research
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action TNFRSF18 protein stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Preclinical Cancer

Most Recent Events

  • 13 Sep 2017 Incyte Corporation plans a phase I/II trial for Cancer (Metastatic disease, Late-stage disease) in USA (NCT03277352)
  • 13 Apr 2017 Phase-I/II clinical trials in Solid tumours (Metastatic disease, Second-line therapy or greater, Late-stage disease) in USA (IV) (NCT03126110)
  • 14 Feb 2017 Incyte and Agenus amend licensing agreement from profit-sharing agreement to royalty bearing agreement
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