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CDX 1140

Drug Profile

CDX 1140

Alternative Names: CDX-1140

Latest Information Update: 27 Feb 2024

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At a glance

  • Originator Celldex Therapeutics Inc
  • Developer Albert Einstein College of Medicine; Celldex Therapeutics Inc; Merck & Co; University of Texas Southwestern Medical Center; Washington University School of Medicine
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action CD40 antigen stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Lymphoma; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Pancreatic cancer; Solid tumours; Triple negative breast cancer

Most Recent Events

  • 21 Nov 2023 Washington University School of Medicine, in collaboration with Celldex Therapeutics and The Foundation for Barnes-Jewish Hospital terminates a phase II trial in Pancreatic cancer (Combination therapy) in USA (IV; infusion) due to Celldex decision (NCT04536077)
  • 23 Jun 2023 Albert Einstein College of Medicine and Celldex Therapeutics terminates phase I/II trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA due to low accural (Parenteral) (NCT04491084)
  • 09 Nov 2022 Discontinued - Phase-I for Lymphoma (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral)
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