Drug Profile


Alternative Names: 11-1F4; CAEL101; Ch mAb 11-1F4; Chimeric fibril reactive monoclonal antibody 11-1F4 -Caelum Biosciences

Latest Information Update: 14 Dec 2017

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At a glance

  • Originator Columbia University
  • Developer Caelum Biosciences; Columbia University; National Cancer Institute (USA)
  • Class Monoclonal antibodies
  • Mechanism of Action Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyloidosis; Amyloid light-chain amyloidosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Amyloid light-chain amyloidosis

Most Recent Events

  • 11 Dec 2017 CAEL-101 is available for licensing as of 11 Dec 2017.
  • 11 Dec 2017 Adverse events and efficacy data from a phase Ia/Ib trial in amyloid light chain amyloidosis presented at the 59th American Society of Hematology Annual Meeting (ASH-2017)
  • 11 Dec 2017 Caelum Biosciences plans a phase IIb/III trial for amyloid light chain amyloidosis in the second half of 2018
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