IONIS ANGPTL3LRx

Drug Profile

IONIS ANGPTL3LRx

Alternative Names: AKCEA-ANGPTL3-LRX; IONIS-ANGPTL3-LRX; ISIS-703802

Latest Information Update: 21 Dec 2017

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer Akcea Therapeutics; Ionis Pharmaceuticals
  • Class Antihyperlipidaemics; Antisense oligonucleotides
  • Mechanism of Action ANGPTL3 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hyperlipoproteinaemia type I; Hypertriglyceridaemia; Non-alcoholic fatty liver disease; Type 2 diabetes mellitus
  • Phase I/II Hyperlipoproteinaemia type IIa

Most Recent Events

  • 14 Dec 2017 Phase-II clinical trials in Hypertriglyceridaemia, Non-alcoholic fatty liver disease and Type-2 diabetes mellitus in USA (SC) (NCT03371355)
  • 13 Nov 2017 Phase-II clinical trials in Hyperlipoproteinaemia type I (Familial chylomicronemia syndrome) in Canada (SC) (NCT03360747)
  • 13 Nov 2017 Akcea Therapeutics plans to initiate phase II clinical trials for Lipodystrophy and Hyperlipoproteinaemia-type-IIa (Homozygous familial hypercholesterolemia)
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