Research programme: farnesoid-X-activated receptor agonists - Metacrine

Drug Profile

Research programme: farnesoid-X-activated receptor agonists - Metacrine

Alternative Names: M 480; MET 409

Latest Information Update: 12 Oct 2017

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At a glance

  • Originator Metacrine
  • Class Antifibrotics; Small molecules
  • Mechanism of Action Farnesoid X-activated receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Fibrosis; Non-alcoholic steatohepatitis

Most Recent Events

  • 10 Oct 2017 Preclinical trials in Fibrosis in USA (unspecified route)
  • 10 Oct 2017 Metacrine plans a clinical trial of MET 409 in the first half of 2018
  • 19 Apr 2017 Pharmacodynamics data from a preclinical study of M 480 in Non-alcoholic steatohepatitis presented at the International Liver Congress 2017
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