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Selpercatinib - Loxo oncology

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Drug Profile

Selpercatinib - Loxo oncology

Alternative Names: LOXO 292; LY-3527723; RETEVMO; Retsevmo

Latest Information Update: 11 Mar 2024

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At a glance

  • Originator Array BioPharma
  • Developer Eli Lilly and Company; Loxo Oncology
  • Class Antineoplastics; Aza compounds; Ethers; Nitriles; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Proto oncogene protein c ret inhibitors; Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer; Pancreatic cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer; Solid tumours; Thyroid cancer
  • Phase I/II CNS cancer

Most Recent Events

  • 18 Jan 2024 Updated efficacy and adverse events data from a phase I/II trial in Solid tumours presented at the 2024 Gastrointestinal Cancers Symposium (ASCO-GCS-2024)
  • 31 Oct 2023 Eli Lilly and Company completes a phase I pharmacokinetics trial (In volunteers) in USA (PO) (NCT05906836)
  • 21 Oct 2023 Efficacy data from a phase III LIBRETTO-431 trial in Non-small cell lung cancer released by Eli Lilly and Company
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