Drug Profile


Alternative Names: Anti-CD123 CAR-T Cells-Cellectis

Latest Information Update: 08 Nov 2017

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At a glance

  • Originator Cellectis
  • Class Antineoplastics; CAR-T cell therapies
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Gene transference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Haematological malignancies

Most Recent Events

  • 06 Nov 2017 The US FDA removes clinical hold on both the phase I trials for Acute myeloid leukaemia and Blastic plasmacytoid dendritic cell neoplasm
  • 04 Sep 2017 The US FDA places a clinical hold on studies of UCART 123 for Acute myeloid leukaemia and blastic plasmacytoid dendritic cell neoplasm, following a fatality
  • 04 Sep 2017 Adverse events data from two phase I trials in Acute myeloid leukaemia and blastic plasmacytoid dendritic cell neoplasm released by Cellectis
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