Drug Profile
Ivonescimab - Akeso Biopharma
Alternative Names: AK-112; PD-1/VEGF bi-specific antibody - Akeso Biopharma; SMT-112Latest Information Update: 23 Apr 2024
Price :
$50
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At a glance
- Originator Akeso Biopharma
- Developer Akeso Biopharma; Summit Therapeutics; Tianjin Medical University Cancer Institute and Hospital
- Class Antineoplastics; Bispecific antibodies; Immunotherapies
- Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death-1 receptor antagonists; T lymphocyte stimulants; Vascular endothelial growth factor receptor antagonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
- Available For Licensing Yes
Highest Development Phases
- Preregistration Non-small cell lung cancer
- Phase II Colorectal cancer; Gynaecological cancer; Liver cancer; Triple negative breast cancer
- Phase I/II Ovarian cancer; Solid tumours
- Phase I Small cell lung cancer
Most Recent Events
- 14 Mar 2024 Phase-II clinical trials in Liver cancer (Inoperable/Unresectable, First-line therapy, Late-stage disease, Combination therapy) in China (IV) (NCT06375486)
- 13 Mar 2024 Phase-III clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in France (IV)
- 13 Mar 2024 Phase-III clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Italy (IV) (NCT05184712)