A multicenter, randomized, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427, 857 [maraviroc], in combination with optimized background therapy versus optimized background therapy alone for the treatment of antiretroviral-experienced HIV-1 infected subjects.

Trial Profile

A multicenter, randomized, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427, 857 [maraviroc], in combination with optimized background therapy versus optimized background therapy alone for the treatment of antiretroviral-experienced HIV-1 infected subjects.

Completed
Phase of Trial: Phase II/III

Latest Information Update: 12 Sep 2015

At a glance

  • Drugs Maraviroc (Primary) ; Antiretrovirals
  • Indications HIV-1 infections
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms MOTIVATE-1
  • Most Recent Events

    • 07 Jun 2017 Biomarkers information updated
    • 12 Sep 2015 Pooled analysis (SINGLE + MOTIVATE); Missing CD4+ cell response, results published in the HIV Clinical Trials.
    • 27 Jul 2012 Results from a pooled analysis of MOTIVATE-1 and -2 presented at the 19th International AIDS Conference.
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