A randomized, double-blind, multicenter study comparing MDX-010 [ipilimumab] monotherapy, MDX-010 in combination with a melanoma peptide vaccine [MDX 1379], and melanoma vaccine monotherapy in HLA-A2 0201-positive patients with previously treated unresectable stage III or IV melanoma.

Trial Profile

A randomized, double-blind, multicenter study comparing MDX-010 [ipilimumab] monotherapy, MDX-010 in combination with a melanoma peptide vaccine [MDX 1379], and melanoma vaccine monotherapy in HLA-A2 0201-positive patients with previously treated unresectable stage III or IV melanoma.

Completed
Phase of Trial: Phase III

Latest Information Update: 13 May 2016

At a glance

  • Drugs Ipilimumab (Primary) ; MDX 1379
  • Indications Malignant melanoma
  • Focus Registrational; Therapeutic Use
  • Sponsors Bristol-Myers Squibb
  • Most Recent Events

    • 07 Jun 2017 Biomarkers information updated
    • 13 May 2016 Results of comparison of overall survival data for ipilimumab, vemurafenib and dacarbazine from three trials including this published in the BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
    • 01 Dec 2015 Results related to immunoregulatory predictors of efficacy from NCT00094653 and NCT00495066 published in the Cancer Research.
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