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Young Adult With Acute Lymphoblastic Leukemia (ALL) : a Multicentric Protocol. GRAALL [Group for Research on Adult Acute Lymphoblastic Leukemia] 2005 : T ALL or B ALL Non Ph GRAALL 2005 R : B ALL Non Ph CD20+ GRAAPH 2005 : ALL Ph

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Trial Profile

Young Adult With Acute Lymphoblastic Leukemia (ALL) : a Multicentric Protocol. GRAALL [Group for Research on Adult Acute Lymphoblastic Leukemia] 2005 : T ALL or B ALL Non Ph GRAALL 2005 R : B ALL Non Ph CD20+ GRAAPH 2005 : ALL Ph

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 23 May 2023

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At a glance

  • Drugs Imatinib (Primary) ; Rituximab (Primary) ; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Methotrexate; Vincristine
  • Indications Precursor B-cell lymphoblastic leukaemia-lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma; Precursor T-cell lymphoblastic leukaemia-lymphoma
  • Focus Therapeutic Use

    • Most Recent Events

    • 19 May 2023 Results evaluating its efficacy ponatinib versus imatinib-based regimens using a matching adjusted indirect comparison from NCT00038610 , NCT00327678, NCT01424982 and NCT01641107 , published in the Advances in Therapy
    • 09 Nov 2022 Results of a matched adjusting Indirect comparison in two studies (GRAAPH-2005 and NCT00038610) assessing efficacy of ponatinib as frontline treatment in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia were presented at the 25th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research.
    • 22 Mar 2022 Results assessing RNA-seq and whole-genome analyses in a large cohort of unresolved B-ALL in patients from from NCT00327678 and other studies, published in the Blood
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