A prospective, open, randomized, multicenter study comparing the effects of everolimus versus mycophenolate sodium as compared to ciclosporin as maintenance therapy in renal allograft recipients, on chronic allograft damage and cardiovascular parameters.

Trial Profile

A prospective, open, randomized, multicenter study comparing the effects of everolimus versus mycophenolate sodium as compared to ciclosporin as maintenance therapy in renal allograft recipients, on chronic allograft damage and cardiovascular parameters.

Completed
Phase of Trial: Phase III

Latest Information Update: 17 Sep 2016

At a glance

  • Drugs Ciclosporin (Primary) ; Everolimus (Primary) ; Mycophenolate sodium (Primary) ; Prednisolone
  • Indications Renal transplant rejection
  • Focus Adverse reactions
  • Acronyms MECANO
  • Most Recent Events

    • 17 Sep 2016 Results published in the American Journal of Transplantation
    • 17 Sep 2016 Primary endpoint has been met. (Degree of inflammation and fibrosis and degree of arteriolar hyalinosis in renal biopsies taken at 6 and 24 months after implantation for prednisolone/Everolimus (P/EVL) arm), according to Results published in the American Journal of Transplantation.
    • 17 Sep 2016 Results published in the American Journal of Transplantation
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