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A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-ranging Study of SB-480848, an Oral Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Inhibitor, in Subjects With Stable Coronary Heart Disease (CHD) or CHD-risk Equivalent to Examine Chronic Inhibition of Lp-PLA2 Effects on Circulating Biomarkers Associated With Cardiovascular Risk, Safety and Tolerability Over 12 Weeks

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Trial Profile

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-ranging Study of SB-480848, an Oral Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Inhibitor, in Subjects With Stable Coronary Heart Disease (CHD) or CHD-risk Equivalent to Examine Chronic Inhibition of Lp-PLA2 Effects on Circulating Biomarkers Associated With Cardiovascular Risk, Safety and Tolerability Over 12 Weeks

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 01 Sep 2023

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At a glance

  • Drugs Darapladib (Primary) ; Atorvastatin
  • Indications Atherosclerosis; Coronary disorders
  • Focus Biomarker; Therapeutic Use
  • Sponsors Glaxo Research and Development Limited; GlaxoSmithKline; GSK

    • Most Recent Events

    • 04 Jun 2019 Trial has been discontinued in UK according to European Clinical Trials Database record.
    • 01 Apr 2008 Results presented at ACC in 2008
    • 26 Nov 2006 New trial record.
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