A Multicenter, Randomized, Double-Period, Double-Blind Study to Determine the Optimal Protocol for Treatment Initiation With Methotrexate and Adalimumab Combination Therapy in Patients With Early Rheumatoid Arthritis - OPTIMA.

Trial Profile

A Multicenter, Randomized, Double-Period, Double-Blind Study to Determine the Optimal Protocol for Treatment Initiation With Methotrexate and Adalimumab Combination Therapy in Patients With Early Rheumatoid Arthritis - OPTIMA.

Completed
Phase of Trial: Phase IV

Latest Information Update: 16 Nov 2017

At a glance

  • Drugs Adalimumab (Primary) ; Methotrexate
  • Indications Rheumatoid arthritis
  • Focus Therapeutic Use
  • Acronyms OPTIMA
  • Sponsors Abbott Laboratories
  • Most Recent Events

    • 16 Nov 2017 Results of post hoc analysis assessing the efficacy and tolerability of methotrexate + continuing adalimumab versus methotrexate alone in patients with early rheumatoid arthritis [RA], were published in the Annals of the Rheumatic Diseases.
    • 08 Nov 2017 Results of post hoc analysis of OPTIMA and PREMIER trials assessing clinical, functional, and radiographic outcomes based on initial time to low disease activity (LDA) attainment presented at the 81st American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting
    • 17 Jun 2017 Results of long-term outcomes data from two studies (PREMIER and OPTIMA) presented at the 18th Annual Congress of the European League Against Rheumatism
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